منابع مشابه
Induced immunologic response to tumors.
A tumoricidal system has been described utilizing a two-step process which, first, specifically alters the antigenic nature of a tumor cell and, second, adds a heterologous cytotoxic anti body without affecting normal cells. The antigenic structure of the tumor cell is altered by the nitrogen mustard, L-phenylalanine mustard, and a specific antibody is made to this mustard by injecting it into ...
متن کاملTargeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.
BACKGROUND Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the donor prevents AVR in a mouse-to-rat cardiac xenotransplantation model. By 3...
متن کاملThe host immunologic response to West Nile encephalitis virus.
West Nile encephalitis virus (WNV) is a small, enveloped, mosquito-transmitted, positive-polarity RNA virus of the Flaviviridae family. This virus is closely related to other arthropod-borne viruses that cause human disease including Dengue, Yellow fever, and Japanese encephalitis viruses. WNV cycles in nature between mosquitoes and birds, but also infects human, horses, and other vertebrates. ...
متن کاملTumor immunologic heterogeneity influences response to radiation and combination immunotherapy
Clinical trials of CTLA-4 and PD-1/PD-L1 antibodies (Ab) have shown responses limited to 10-30% of patients. Increasing evidence suggests radiation (RT) can enhance responses to checkpoint therapies. However, understanding of tumor-derived factors that influence response is limited, and many preclinical models are designed to be immunogenic. We sought to develop a model of immunologic heterogen...
متن کاملImmunologic response of patients with acute leukemia to platelet transfusions.
platelet concentrates from random donors over a period of 5 to 32 wk (an average of 31 transfusions per patient). All nine developed lymphocytotoxic activity (presumably HL-A antibodies) in their serum against cells from a panel of 40 selected donors within 20-50 days after transfusions were begun. Lymphocytotoxic activity markedly diminished in the sera of seven surviving patients over a perio...
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ژورنال
عنوان ژورنال: ILAR Journal
سال: 1995
ISSN: 1084-2020
DOI: 10.1093/ilar.37.1.16